ABSTRACTAbout "Nano Pill Bug"
『 "Nano Pill Bug" is a robot to capture and protect miRNA 』
Background
In recent years, early detection technologies based on the analysis of miRNA expression patterns have emerged for various diseases, including cancer. These methods are limited to miRNAs that are protected from RNases by proteins or lipids, while miRNAs that are unprotected remain largely unexplored.
Here we propose a device, the “Nano Pill Bug”, that focuses on protecting miRNAs from degradation by RNases. Inspired by pill bugs, this device captures miRNA and rolls up and protects it
Structure
The structure consists of two DNA Origami sheets and several stopper DNA strands connecting them. Each sheet has a two-layer structure, and its bend is formed by differences in the number of bases, creating a tube-like shape. These two bent sheets are held in place by pre-arranged stopper DNA, which maintains the flat structure by balancing the tension between the sheets. When the stopper DNA is replaced by miRNA through a strand displacement reaction, the tension between the sheets is released. This allows the miRNA to be encapsulated within the cylindrical structure, protecting it from degradation by RNase.
Vision
We are developing Nano Pill Bug, a nanorobot that protects miRNAs that are present in minute quantities as the planar structure curls up rapidly. By extending the functionality of the Nano Pill Bug to target small molecules such as DNA and proteins, the Nano Pill Bug has the potential for a wide range of applications.
MOVIEOur Project video
CONTENTS
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